Protein Details: Voltage-gated Potassium channel-interacting protein 2

Protein ID

ICDB_Pro_1531

Protein Name

Voltage-gated Potassium channel-interacting protein 2

Gene Name

Kcnip2; Kchip2

Organism

Mus musculus (Mouse)

Length

270 amino acids

AlphaFoldDB

AF-Q9JJ69-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner . In vitro; modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart . Required for normal protein levels of KCND2 in the heart ventricle

Sequence

MRGQGRKESLSDSRDLDGSYDQLTGHPPGPSKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRRELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQQDENIMRSMQLFDNVI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

153;155;157;159;164;189;191;193;195;200;237;239;241;248

Disease

Location

Detected in brain (at protein level) (PubMed:23713033). Expressed in brain. Highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus; but expressed at low levels in cerebellum. Also expressed in heart. According to PubMed:11747815 expressed in heart at much higher levels than in brain with a preferential expression in the myocardium.

DOI ID

10.1006/bbrc.2001.4558; 10.1016/s0092-8674(01)00588-8; 10.1161/01.res.0000012664.05949.e0; 10.1016/j.molbrainres.2004.06.024; 10.4161/chan.3.4.9553; 10.1016/j.cell.2010.12.001; 10.1523/jneurosci.2487-10.2010; 10.1113/jphysiol.2013.255836

RefSeq

NP_001263287.1 [Q9JJ69-4]; NP_109641.2; NP_663749.1; NP_663750.1; XP_017173804.1